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KMID : 0043320040270111120
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1120 ~ p.1122
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Anti-Diabetic Activities of Fucosterol from Pelvetia siliquosa
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Lee Yeon-Sil
Shin Kuk-Hyun
Kim Bak-Kwang
Lee Sang-Hyun
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Abstract
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Fucosterol isolated from Pelvetia siliquosa was tested for its anti-diabetic activity in vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algae P. siliquosa.
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KEYWORD
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Pelvetia siliquosa, Fucaceae, Fucosterol, Anti-diabetic activity
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